MyBioSource.com's IL 11 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Immunohistochemistry. The IL 11 Antibody was generated using IL-11, IL11, and Interleukin 11 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Description: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
Function: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Subunit Structure: Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.
Similarity: Belongs to the IL-6 superfamily